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Mycoplasma is a unique group of bacteria that lacks a cell wall, making them highly flexible and naturally resistant to certain antibiotics, such as penicillin. In animal farming—particularly poultry and swine—mycoplasma infections can cause serious problems, including chronic respiratory disease, reduced production performance, and increased susceptibility to secondary infections. 

Common Mycoplasma Species in Livestock: 

• Mycoplasma gallisepticum (MG): Mainly affects poultry and causes chronic respiratory disease.
• Mycoplasma hyopneumoniae: The primary cause of enzootic pneumonia in swine.
• Mycoplasma synoviae: Affects poultry joints and the respiratory tract. 

Mycoplasma infections often lead to significant economic losses due to reduced weight gain, increased feed conversion ratio (FCR), and even mortality. Mycoplasma also presents an additional threat due to its capacity to establish latent or chronic infections, which may reactivate under conditions of immunosuppression or physiological stress in the host.

Prevention is key since Mycoplasma is difficult to eliminate with conventional antibiotics and can spread easily through direct contact or airborne transmission. Preventive strategies include strict biosecurity measures and the use of targeted, effective antibiotics, one of which is Tylvalosin tartrate. 

Tylvalosin tartrate is a macrolide antibiotic with a broad spectrum of activity against Gram-positive bacteria and specific organisms such as Mycoplasma. Compared to other macrolides, Tylvalosin offers several advantages: 

• Rapid distribution to target tissues, especially the lungs 
• Effective targeting of intracellular bacteria due to their elevated intracellular activity minimizes the likelihood of disease recurrence.
• Additional anti-inflammatory properties
• Lower yet effective dosage
• Short withdrawal period 

Tylvalosin tartrate is typically administered through feed or drinking water, making it practical for large-scale livestock operations. Tylvalosin tartrate is effective in the following scenarios: 

• Preventing clinical infections: Administering Tylvalosin during critical periods (such as seasonal changes or high-stress events) helps suppress Mycoplasma growth before severe symptoms occur.
• Reducing transmission: By controlling bacterial populations in the animal's body, the risk of spreading between individuals is minimized.
• Supporting eradication programs: On farms pursuing Mycoplasma-free status, Tylvalosin tartrate is used as part of a strategic program alongside strict biosecurity and continuous monitoring. 

In addition, the use of Tylvalosin tartrate also contributes to improved production performance by reducing the subclinical impact of Mycoplasma infections, such as poor feed efficiency and weight loss. 

To help tackle the challenges posed by Mycoplasma, Agrinusa offers Valogrin, a product containing Tylvalosin tartrate—an effective solution for controlling Mycoplasma, improving livestock performance, and enhancing overall herd health. 

An effective prevention strategy relies on a combination of strict biosecurity, proper vaccination programs, and the responsible use of antibiotics. With an integrated approach, the harmful impact of Mycoplasma infections can be significantly reduced.